Enclomiphene and Fertility: The Practical Guide
Enclomiphene is one of the only hormone therapies that raises testosterone while preserving, often improving, male fertility.
Why fertility matters here
Testosterone replacement therapy almost always suppresses sperm production within months. For men under 40 who plan to have children, this is a major decision factor.
How enclomiphene affects sperm production
By stimulating both LH and FSH, enclomiphene drives the two testicular cell types that matter, Leydig cells (testosterone) and Sertoli cells (sperm). Trials show sperm concentration, motility, and morphology either stay the same or improve on enclomiphene.
This is the entire reason urologists used clomiphene off-label for years before enclomiphene became available as a compounded medication.
Realistic expectations
If you are trying to conceive, the practitioner may run a baseline semen analysis and recheck at three months. For most men, enclomiphene is compatible with conception during therapy.
Frequently asked questions
Is enclomiphene used in fertility clinics?
Yes, clomiphene and enclomiphene have been used to treat male factor infertility for decades.
Can I conceive while on enclomiphene?
In most cases, yes. The medication does not block conception.
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