Enclomiphene: The Complete 2026 Men's Guide
Enclomiphene is the SERM that raises a man's own testosterone instead of replacing it. This guide covers how it works, dosing, side effects, cost, fertility, and how it compares with TRT.
What enclomiphene actually is
Enclomiphene is the trans-isomer of clomiphene citrate, a selective estrogen receptor modulator (SERM). In men, it blocks estrogen feedback at the hypothalamus and pituitary, which triggers a release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH then signals the testes to produce more testosterone. FSH supports sperm production.
Unlike testosterone replacement therapy, enclomiphene does not introduce exogenous testosterone. The body keeps making its own, usually more of it. This is the entire mechanism of action and the reason enclomiphene is often the first option a licensed practitioner considers for younger men who want to preserve fertility.
Enclomiphene is taken orally as a daily capsule, typically at 12.5 mg or 25 mg. It is non-controlled, does not require injections, and is compounded at state-licensed pharmacies.
Who enclomiphene is usually for
Most men who do well on enclomiphene share a similar profile: total testosterone in the low-normal range (often 200–450 ng/dL), LH that is normal or low, and a desire to either preserve fertility or avoid the daily commitment of injections.
Men who already have primary hypogonadism. Meaning the testes themselves cannot produce testosterone regardless of LH signal, typically do not respond to enclomiphene. For them, TRT is the more honest option. A licensed practitioner reads the intake and bloodwork together before recommending either route.
Dosing: 12.5 mg vs 25 mg
The two doses Selvara offers are 12.5 mg and 25 mg taken once daily. Most men start at 12.5 mg, retest at six to eight weeks, and only move to 25 mg if total testosterone has not climbed meaningfully or symptoms persist.
There is a clinical reason to prefer the lower dose when it works: higher LH stimulation can also raise estradiol, which is the most common cause of side effects on enclomiphene. Staying on the smallest effective dose is the practical rule.
What to expect on the labs
On a working dose of enclomiphene, total testosterone often increases by 100–200 percent from baseline within three months, with peer-reviewed trials showing rises into the 400–800 ng/dL range. LH and FSH rise concurrently. Sperm parameters typically improve or are preserved.
Estradiol can also rise; if it climbs disproportionately and the man feels off (nipple sensitivity, water retention, mood instability), the practitioner will either drop the dose or, in select cases, add a low dose of anastrozole.
Side effects worth taking seriously
The most reported issues are visual disturbances (bright flashes, transient blurring), headaches, mood changes, and breast tenderness. Most are mild and dose-dependent, the lower dose resolves most of them.
Visual symptoms are the one signal that should prompt an immediate chat with the practitioner. Persistent visual changes warrant stopping the medication and reassessing.
Enclomiphene versus TRT
TRT delivers testosterone directly. Levels are predictable, dosing is straightforward, and most men feel a clear difference within four to six weeks. The trade-off: the hypothalamic-pituitary-gonadal axis shuts down, the testes shrink slightly, and natural sperm production usually stops.
Enclomiphene works upstream. It is less powerful as a peak-testosterone tool but preserves fertility, keeps the testes active, and is reversible. Men who want children in the next several years almost always start here.
Cost and refills at Selvara
Selvara prices enclomiphene at $129 per month for 12.5 mg and $139 per month for 25 mg. There is no membership fee, no subscription, and no card on file until a licensed practitioner has reviewed your intake and you have approved the protocol.
Refills are automatic at the cadence your practitioner sets and can be adjusted in chat at any time.
Frequently asked questions
Does enclomiphene work as well as TRT?
For raising testosterone into a clinically meaningful range, enclomiphene is typically less potent than TRT but still strong: trials show 100–200% increases from baseline. For preserving fertility and avoiding injections, it is the only option.
Will enclomiphene shut down my natural testosterone?
No. It does the opposite. It amplifies your body's own LH and FSH signal, which tells the testes to produce more testosterone.
Is enclomiphene legal in the US?
Enclomiphene as a compounded medication is legal when prepared by a state-licensed compounding pharmacy on the prescription of a licensed practitioner. It is not FDA approved as a finished branded drug.
How fast will I feel a difference?
Most men feel something at four to six weeks. Lab changes show up sooner. Full clinical response is usually evaluated at three months.
Free intake. Practitioner review in 24 hours.
No card on file until a licensed Selvara practitioner has approved a protocol, and you have approved it.
Begin intake, free- Wiehle RD et al., "Enclomiphene citrate stimulates testosterone production while preventing oligospermia," Fertility and Sterility, 2014.
- Kim ED et al., "Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men," BJU International, 2016.