PT-141 (Bremelanotide): The Libido Drug That Isn't a PDE5 Inhibitor
PT-141 works in the brain, not in the blood vessels. For men whose problem is desire rather than erection mechanics, it's the right tool.
What it is
PT-141 (bremelanotide) is a synthetic peptide that activates melanocortin receptors in the central nervous system. The effect is increased sexual desire and arousal. It does not directly cause erections, it makes you want them.
Who should consider it
Men whose erectile mechanics work fine when desire is present, but whose desire has declined. Men who don't respond fully to PDE5 inhibitors because the problem is upstream. Men on TRT who want additional libido support.
Dosing
Subcutaneous injection 30–60 minutes before activity. Some men prefer the nasal spray form.
Side effects
Nausea (most common, dose-dependent). Flushing. Transient blood pressure elevation. Mild facial darkening with frequent use.
Cost
$199 at Selvara.
Frequently asked questions
Can I combine it with tadalafil?
Yes. Many men do. Desire from PT-141, mechanics from tadalafil.
Is it FDA approved?
Branded bremelanotide (Vyleesi) is FDA-approved for women. Selvara dispenses compounded PT-141 for men under practitioner prescription.
Free intake. Practitioner review in 24 hours.
No card on file until a licensed Selvara practitioner has approved a protocol, and you have approved it.
Begin intake, free