Testosterone Cypionate vs Cream: Which TRT Delivery Is Right?
Injectable testosterone cypionate and transdermal cream both work. The difference is in absorption, convenience, and how stable you want your levels.
The two delivery routes
Selvara prescribes two forms of testosterone: injectable cypionate (subcutaneous or intramuscular, once or twice weekly) and a daily transdermal cream applied to the scrotum or upper inner thigh.
Cypionate: the workhorse
Cypionate has been the dominant form of TRT for decades. Pharmacokinetics are well-understood, peak-trough variation is manageable with twice-weekly dosing, and the cost is the lowest of any reliable delivery.
The trade-off is the weekly (or twice-weekly) injection. Most men adapt to subcutaneous dosing within a week. Needles are 27–29 gauge. Small enough that most men describe them as a non-issue after the first month.
Cream: the no-needle option
Testosterone cream applied to the scrotum produces excellent absorption, scrotal skin is roughly five times more permeable than other skin. Upper-thigh application works but produces more variable levels.
The honest downsides: partner transfer is a real risk if the man does not wash hands and let the cream dry, and absorption can vary day to day. Some men test fine on cream; others find the variability bothers them.
How to decide
If you are needle-averse and willing to apply cream daily without missing days, start with cream. If you want the most predictable bloodwork and the lowest cost, start with cypionate.
Frequently asked questions
Can I switch later?
Yes. The practitioner converts your dose between routes.
Does cream raise estradiol more?
Both routes can. Body fat matters more than the route.
Free intake. Practitioner review in 24 hours.
No card on file until a licensed Selvara practitioner has approved a protocol, and you have approved it.
Begin intake, free